Name
Title | ||
|---|---|---|
Most of the tight positional conservation of transcription factor binding sites near the transcription start site reflects their co-localization within regulatory modules. |
Abstract | ||
|---|---|---|
Gene duplication and convergent evolution within a genome provide obvious biological mechanisms for replicating an RM near the TSS that binds a particular TF subunit. Of all intersections of our 43 significant gene groups, 85% were significantly enriched, with 73% of the significant enrichments independently validated by gene ontology. The co-localization of TFBSs within RMs therefore likely explains much of the tight TFBS positional preferences near the TSS. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1186/s12859-016-1354-5 | BMC Bioinformatics |
Keywords | Field | DocType |
Positional preference,Transcription factor binding site,Transcription start site | Gene,Transcription (biology),Biology,DNA binding site,Regulation of gene expression,Bioinformatics,Gene duplication,Genetics,DNA microarray,Transcription factor,Sequence analysis | Journal |
Volume | Issue | ISSN |
17 | 1 | 1471-2105 |
Citations | PageRank | References |
0 | 0.34 | 20 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Natalia Acevedo-Luna | 1 | 0 | 0.34 |
| Leonardo Mariño-Ramírez | 2 | 0 | 1.01 |
| Armand Halbert | 3 | 0 | 0.34 |
| Ulla Hansen | 4 | 52 | 6.85 |
| David Landsman | 5 | 618 | 78.83 |
| John L. Spouge | 6 | 110 | 10.73 |