Title
Negative binomial mixed models for analyzing microbiome count data.
Abstract
We evaluate and demonstrate the proposed method via extensive simulation studies and the application to mouse gut microbiome data. The results show that the proposed method has desirable properties and outperform the previously used methods in terms of both empirical power and Type I error. The method has been incorporated into the freely available R package BhGLM ( http://www.ssg.uab.edu/bhglm/ and http://github.com/abbyyan3/BhGLM ), providing a useful tool for analyzing microbiome data.
Year
DOI
Venue
2017
10.1186/s12859-016-1441-7
BMC Bioinformatics
Keywords
Field
DocType
Correlated measures,Count data,Metagenomics,Microbiome,Negative binomial model,Penalized Quasi-likelihood,Random effects
Data mining,Random effects model,Computer science,Microbiome,Metagenomics,Mixed model,Negative binomial distribution,Count data,Bioinformatics,Type I and type II errors,Generalized linear mixed model
Journal
Volume
Issue
ISSN
18
1
1471-2105
Citations 
PageRank 
References 
3
0.52
10
Authors
7
Name
Order
Citations
PageRank
Xinyan Zhang192.47
Himel Mallick232.21
Zaixiang Tang371.56
Lei Zhang4253.00
Xiangqin Cui530.52
Andrew K. Benson6121.16
Nengjun Yi7207.67