Title
Model based heritability scores for high-throughput sequencing data.
Abstract
The models and methods we investigated in this manuscript is applicable and extendable to sequencing experiments where some biological replicates are available and the environmental variation is properly controlled. The CP-fit approach for assessing heritability was implemented for the first time to our knowledge. All the methods presented, as well as the generation of simulated sequencing data under either negative binomial or compound Poisson mixed models, are provided in the R package HeritSeq.
Year
DOI
Venue
2017
10.1186/s12859-017-1539-6
BMC Bioinformatics
Keywords
Field
DocType
Compound Poisson mixed model,Heritability,Negative binomial mixed model,RNAseq,Recombinant inbred panel,Variance partition coefficient
Heritability,Quantitative trait locus,Biology,Linear model,Trait,Mixed model,Negative binomial distribution,Poisson distribution,Bioinformatics,Expression quantitative trait loci,Genetics
Journal
Volume
Issue
ISSN
18
1
1471-2105
Citations 
PageRank 
References 
0
0.34
7
Authors
9