Name
Title | ||
|---|---|---|
Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait. |
Abstract | ||
|---|---|---|
Resting-state functional connectivity (rsFC) is widely used to examine cerebral functional organization. The imaging literature has described lateralization of insula activations during cognitive and affective processing. Evidence appears to support a role of the right-hemispheric insula in attentional orientation to salient stimulus, interoception, and physiological arousal, and a role of the left-hemispheric insula in cognitive and affective control, as well as perspective taking. In this study, in a large data set of healthy adults, we examined lateralization of the rsFC of the anterior insula (AI) by computing a laterality index (LI) of connectivity with 54 regions from the Automated Anatomic Labeling atlas. At a corrected threshold (p < 0.001), the AI is left lateralized in connectivity with the dorsomedial prefrontal cortex, superior frontal gyms, inferior frontal cortex, and posterior orbital gyms and right lateralized in connectivity with the postcentral gyms, supramarginal gyms, and superior parietal lobule. In gender differences, women, but not men, showed right-lateralized connectivity to the thalamus. Furthermore, in a subgroup of participants assessed by the tridimensional personality questionnaire, novelty seeking is correlated with the extent of left lateralization of AI connectivity to the pallidum and putamen in men and with the extent of right lateralization of AI connectivity to the parahippocampal gyrus in women. These findings support hemispheric functional differentiation of the AI. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1089/brain.2016.0443 | BRAIN CONNECTIVITY |
Keywords | Field | DocType |
aging,hemisphericity,insula,laterality,rsFC,sex difference | Superior frontal gyrus,Insula,Laterality,Neuroscience,Lateralization of brain function,Resting state fMRI,Emotional lateralization,Psychology,Postcentral gyrus,Supramarginal gyrus | Journal |
Volume | Issue | ISSN |
6 | 9 | 2158-0014 |
Citations | PageRank | References |
1 | 0.35 | 0 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Sarah Kann | 1 | 1 | 0.35 |
| Sheng Zhang | 2 | 33 | 4.53 |
| Peter Manza | 3 | 8 | 1.93 |
| Hoi-Chung Leung | 4 | 46 | 6.69 |
| Chiang-shan Ray Li | 5 | 19 | 5.13 |