Title | ||
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Mutantelec: An In Silico Mutation Simulation Platform For Comparative Electrostatic Potential Profiling Of Proteins |
Abstract | ||
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The electrostatic potential plays a key role in many biological processes like determining the affinity of a ligand to a given protein target, and they are responsible for the catalytic activity of many enzymes. Understanding the effect that amino acid mutations will have on the electrostatic potential of a protein, will allow a thorough understanding of which residues are the most important in a protein. MutantElec, is a friendly web application for in silico generation of site-directed mutagenesis of proteins and the comparison of electrostatic potential between the wild type protein and the mutant(s), based on the three-dimensional structure of the protein. The effect of the mutation is evaluated using different approach to the traditional surface map. MutantElec provides a graphical display of the results that allows the visualization of changes occurring at close distance from the mutation and thus uncovers the local and global impact of a specific change. (C) 2017 Wiley Periodicals, Inc. |
Year | DOI | Venue |
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2017 | 10.1002/jcc.24712 | JOURNAL OF COMPUTATIONAL CHEMISTRY |
Keywords | Field | DocType |
Electrostatic potential, site-directed mutagenesis, protein engineering, bioinformatics, rational protein design, p53, PDB | Site-directed mutagenesis,Protein engineering,Computational chemistry,Chemistry,Mutant,Mutagenesis,Computational biology,Protein Data Bank (RCSB PDB),Molecular biology,Wild type,In silico,Mutation | Journal |
Volume | Issue | ISSN |
38 | 7 | 0192-8651 |
Citations | PageRank | References |
0 | 0.34 | 5 |
Authors | ||
7 |
Name | Order | Citations | PageRank |
---|---|---|---|
Braulio Valdebenito-Maturana | 1 | 0 | 0.68 |
Jose Antonio Reyes-Suarez | 2 | 0 | 0.68 |
Jaime Henriquez | 3 | 0 | 0.34 |
David S Holmes | 4 | 4 | 2.56 |
Raquel Quatrini | 5 | 0 | 0.68 |
Ehmke Pohl | 6 | 0 | 1.01 |
Mauricio Arenas-Salinas | 7 | 0 | 0.68 |