Title
Development Of Time-Programmed, Dual-Release System Using Multilayered Fiber Mesh Sheet By Sequential Electrospinning
Abstract
In general clinical pharmacotherapy, multidrug therapy is performed with a view to enhancing drug efficacy or reducing drug's side effects. It is essential that a Drug Delivery System (DDS) for plural drugs be developed to make multidrug therapy more functional and effective. In this review, we summarize prior DDS research and recent developmental efforts for multi-DDS, as well as of the electrospinning (ELSP) method, which has recently attracted great attention as preparation technique of fine polymer fiber in various fields. We also describe a time-programmed dual-drug controlled-release system using multilayered fiber mesh sheets that have been fabricated by a sequential ELSP method we developed. In addition, we address developmental approaches for DDS devices using micromachining technologies (MEMS) as well as issues and future expectations for robotics in DDS research.
Year
DOI
Venue
2010
10.20965/jrm.2010.p0579
JOURNAL OF ROBOTICS AND MECHATRONICS
Keywords
Field
DocType
drug delivery system, multilayered nanofiber meshes, sequential chemotherapy, sequential electrospinning, time-programmed sustained release
Composite material,Fiber,Electrospinning,Materials science
Journal
Volume
Issue
ISSN
22
5
0915-3942
Citations 
PageRank 
References 
0
0.34
0
Authors
2
Name
Order
Citations
PageRank
Tatsuya Okuda100.34
Satoru Kidoaki200.34