Title
Large scale modeling of antimicrobial resistance with interpretable classifiers.
Abstract
Antimicrobial resistance is an important public health concern that has implications in the practice of medicine worldwide. Accurately predicting resistance phenotypes from genome sequences shows great promise in promoting better use of antimicrobial agents, by determining which antibiotics are likely to be effective in specific clinical cases. In healthcare, this would allow for the design of treatment plans tailored for specific individuals, likely resulting in better clinical outcomes for patients with bacterial infections. In this work, we present the recent work of Drouin et al. (2016) on using Set Covering Machines to learn highly interpretable models of antibiotic resistance and complement it by providing a large scale application of their method to the entire PATRIC database. We report prediction results for 36 new datasets and present the Kover AMR platform, a new web-based tool allowing the visualization and interpretation of the generated models.
Year
Venue
Field
2016
arXiv: Genomics
Antibiotic resistance,Health care,Antimicrobial,Genome,Biology,Visualization,Bioinformatics
DocType
Volume
Citations 
Journal
abs/1612.01030
0
PageRank 
References 
Authors
0.34
0
6
Name
Order
Citations
PageRank
Alexandre Drouin1254.66
Frédéric Raymond200.68
Gaël Letarte St-Pierre300.34
Mario Marchand421917.33
Jacques Corbeil517223.67
François Laviolette6103665.93