Title
Maximized Inter-Class Weighted Mean for Fast and Accurate Mitosis Cells Detection in Breast Cancer Histopathology Images.
Abstract
Based on the Nottingham criteria, the number of mitosis cells in histopathological slides is an important factor in diagnosis and grading of breast cancer. For manual grading of mitosis cells, histopathology slides of the tissue are examined by pathologists at 40× magnification for each patient. This task is very difficult and time-consuming even for experts. In this paper, a fully automated method is presented for accurate detection of mitosis cells in histopathology slide images. First a method based on maximum-likelihood is employed for segmentation and extraction of mitosis cell. Then a novel Maximized Inter-class Weighted Mean (MIWM) method is proposed that aims at reducing the number of extracted non-mitosis candidates that results in reducing the false positive mitosis detection rate. Finally, segmented candidates are classified into mitosis and non-mitosis classes by using a support vector machine (SVM) classifier. Experimental results demonstrate a significant improvement in accuracy of mitosis cells detection in different grades of breast cancer histopathological images.
Year
DOI
Venue
2017
10.1007/s10916-017-0773-9
J. Medical Systems
Keywords
Field
DocType
Breast cancer grading,Histopathology image,Maximized inter-class weighted mean,Mitosis detection
Data mining,Mitosis,Pattern recognition,Breast cancer,Segmentation,Histopathology,Support vector machine,Artificial intelligence,Magnification,Medicine,Pathology
Journal
Volume
Issue
ISSN
41
9
1573-689X
Citations 
PageRank 
References 
1
0.35
16
Authors
3
Name
Order
Citations
PageRank
Ramin Nateghi120.70
Habibollah Danyali24911.07
Mohammad Sadegh Helfroush37011.30