Title
Gene regulatory network underlying the immortalization of epithelial cells.
Abstract
Our study strongly suggests that the in vitro tumorigenic transformation of epithelial cells, which strongly correlates with the patterns observed during the pathological progression of epithelial carcinogenesis in vivo, emerges from underlying regulatory networks involved in epithelial trans-differentiation during development.
Year
DOI
Venue
2017
10.1186/s12918-017-0393-5
BMC Systems Biology
Keywords
Field
DocType
Boolean models,Carcinomas,Epigenetic landscape,Gene regulatory networks,Phenotypic attractors
Biology,Phenotype,Mesenchymal stem cell,Systems biology,Cell biology,Cell type,Cellular differentiation,Cell,Bioinformatics,Gene regulatory network,Mutation
Journal
Volume
Issue
ISSN
11
1
1752-0509
Citations 
PageRank 
References 
1
0.41
9
Authors
6