Name
Title | ||
|---|---|---|
Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches. |
Abstract | ||
|---|---|---|
BackgroundPhysiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over physiological fidelity despite the lack of general guidelines relating model design to dynamical predictions. Here we explore the impact of design choice (high vs. low fidelity) on chemical distribution throughout an animal’s organ system. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1186/s12918-017-0407-3 | BMC Systems Biology |
Keywords | Field | DocType |
Diazinon, Exposure Concentration, Fathead Minnow, Body Concentration, Lower Observable Effect Concentration | Fidelity,Computer science,Design choice,Bioinformatics,Low fidelity | Journal |
Volume | Issue | ISSN |
11 | 1 | 1752-0509 |
Citations | PageRank | References |
1 | 0.43 | 1 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Michael A. Rowland | 1 | 1 | 0.77 |
| Edward J. Perkins | 2 | 225 | 20.46 |
| michael mayo | 3 | 1 | 1.45 |