Paper Info
Title
Network topology of NaV1.7 mutations in sodium channel-related painful disorders.
Abstract
BackgroundGain-of-function mutations in SCN9A gene that encodes the voltage-gated sodium channel NaV1.7 have been associated with a wide spectrum of painful syndromes in humans including inherited erythromelalgia, paroxysmal extreme pain disorder and small fibre neuropathy. These mutations change the biophysical properties of NaV1.7 channels leading to hyperexcitability of dorsal root ganglion nociceptors and pain symptoms. There is a need for better understanding of how gain-of-function mutations alter the atomic structure of Nav1.7.
Year
DOI
Venue
2017
10.1186/s12918-016-0382-0
BMC Systems Biology
Keywords
Field
DocType
Sodium channel, Neuropathic pain, Structural modeling, Network analysis
Dorsal root ganglion,Biology,Neuropathic pain,Paroxysmal extreme pain disorder,Nociceptor,SCN9A Gene,Bioinformatics,Sodium channel,Erythromelalgia,Mutation
Journal
Volume
Issue
ISSN
11
1
1752-0509
Citations 
PageRank 
References 
0
0.34
10
Authors
37
Name
Order
Citations
PageRank
Dimos Kapetis100.34
Jenny Sassone200.34
Yang Yang300.34
Barbara Galbardi400.34
Markos N. Xenakis500.34
Ronald L. Westra600.34
Radek Szklarczyk7595.45
Patrick Lindsey800.34
Catharina G. Faber900.34
Monique Gerrits1000.34
Ingemar S. J. Merkies1100.34
Sulayman D. Dib-Hajj1200.34
Massimo Mantegazza1300.34
Stephen G. Waxman1400.34
Giuseppe Lauria1500.34
Michela Taiana1600.34
Margherita Marchi1700.34
Raffaella Lombardi1800.34
Daniele Cazzato1900.34
Filippo Martinelli-Boneschi2000.34
Andrea Zauli21454.18
Ferdinando Clarelli2200.34
Silvia Santoro2300.34
Ignazio Lopez2400.34
Angelo Quattrini2500.68
Janneke Hoeijmakers2600.34
Maurice Sopacua2700.34
Bianca de Greef2800.34
Hubert J. M. Smeets2900.34
Rowida Al Momani3000.34
Jo Michel Vanoevelen3100.34
Ivo Eijkenboom3200.34
Sandrine Cestèle3300.34
Oana Chever3400.34
Rayaz A. Malik3500.34
Mitra Tavakoli3611.03
Dan Ziegler3700.34