Name
Abstract | ||
|---|---|---|
Infection with human immunodeficiency virus (HIV) is associated with neuroimaging alterations. However, little is known about the topological organization of whole-brain networks and the corresponding association with cognition. As such, we examined structural whole-brain white matter connectivity patterns and cognitive performance in 29 HIV+ young adults (mean age = 25.9) with limited or no HIV treatment history. HIV+ participants and demographically similar HIV- controls (n = 16) residing in South Africa underwent magnetic resonance imaging (MRI) and neuropsychological testing. Structural network models were constructed using diffusion MRI-based multifiber tractography and T-1-weighted MRI-based regional gray matter segmentation. Global network measures included whole-brain structural integration, connection strength, and structural segregation. Cognition was measured using a neuropsychological global deficit score (GDS) as well as individual cognitive domains. Results revealed that HIV+ participants exhibited significant disruptions to whole-brain networks, characterized by weaker structural integration (characteristic path length and efficiency), connection strength, and structural segregation (clustering coefficient) than HIV- controls (p <0.05). GDSs and performance on learning/recall tasks were negatively correlated with the clustering coefficient (p <0.05) in HIV+ participants. Results from this study indicate disruption to brain network integrity in treatment-limited HIV+ young adults with corresponding abnormalities in cognitive performance. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1089/brain.2016.0457 | BRAIN CONNECTIVITY |
Keywords | Field | DocType |
cognition,HIV,network analysis,whole-brain connectivity | Brain mapping,Topology,Diffusion MRI,Neuroscience,White matter,Young adult,Neuroimaging,Cognition,Tractography,Medicine,Neuropsychology | Journal |
Volume | Issue | ISSN |
7 | 2 | 2158-0014 |
Citations | PageRank | References |
0 | 0.34 | 10 |
Authors | ||
10 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Laurie M. Baker | 1 | 0 | 0.34 |
| Sarah A. Cooley | 2 | 0 | 0.34 |
| Ryan P. Cabeen | 3 | 47 | 6.05 |
| David H. Laidlaw | 4 | 1781 | 234.58 |
| John A. Joska | 5 | 0 | 0.34 |
| Jacqueline Hoare | 6 | 0 | 0.34 |
| Dan J. Stein | 7 | 12 | 4.29 |
| Jodi M. Heaps-Woodruff | 8 | 0 | 0.34 |
| Lauren E. Salminen | 9 | 0 | 1.01 |
| Robert H. Paul | 10 | 17 | 2.77 |