Name
Title | ||
|---|---|---|
The Neural Correlates Of Emotional Lability In Children With Autism Spectrum Disorder |
Abstract | ||
|---|---|---|
Autism spectrum disorder (ASD) is exceptionally heterogeneous in both clinical and physiopathological presentations. Clinical variability applies to ASD-specific symptoms and frequent comorbid psychopathology such as emotional lability (EL). To date, the physiopathological underpinnings of the co-occurrence of EL and ASD are unknown. As a first step, we examined within-ASD inter-individual variability of EL and its neuronal correlates using resting-state functional magnetic resonance imaging (R-fMRI). We analyzed R-fMRI data from 58 children diagnosed with ASD (5-12 years) in relation to the Conners' Parent Rating Scale EL index. We performed both an a priori amygdala region-of-interest (ROI) analysis, and a multivariate unbiased whole-brain data-driven approach. While no significant brain-behavior relationships were identified regarding amygdala intrinsic functional connectivity (iFC), multivariate whole-brain analyses revealed an extended functional circuitry centered on two regions: middle frontal gyrus (MFG) and posterior insula (PI). Follow-up parametric and nonparametric ROI-analyses of these regions revealed relationships between EL and MFG- and PI-iFC with default, salience, and visual networks suggesting that higher-order cognitive and somatosensory processes are critical for emotion regulation in ASD. We did not detect evidence of amygdala iFC underpinning EL in ASD. However, exploratory whole-brain analyses identified large-scale networks that have been previously reported abnormal in ASD. Future studies should consider EL as a potential source of neuronal heterogeneity in ASD and focus on multinetwork interactions. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1089/brain.2016.0472 | BRAIN CONNECTIVITY |
Keywords | Field | DocType |
autism, CWAS, emotion dysregulation, emotional lability | Autism,Developmental psychology,Neural correlates of consciousness,Neuroscience,Psychopathology,Clinical psychology,Functional magnetic resonance imaging,Connectome,Psychology,Rating scale,Amygdala,Autism spectrum disorder | Journal |
Volume | Issue | ISSN |
7 | 5 | 2158-0014 |
Citations | PageRank | References |
0 | 0.34 | 7 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Randi H. Bennett | 1 | 0 | 0.34 |
| Krishna S. | 2 | 9 | 8.31 |
| Amy K. Roy | 3 | 0 | 0.34 |
| Adriana Di Martino | 4 | 433 | 18.80 |