Name
Abstract | ||
|---|---|---|
Reaction networks taken with mass-action kinetics arise in many settings, such as epidemiology, population biology, and systems of chemical reactions. Bistable reaction networks are posited to underlie biochemical switches, which motivates the following question: Which reaction networks have the capacity for multiple steady states? Mathematically, this asks, from among certain parametrized families of polynomial systems, which admit multiple positive roots? No complete answer is known. This work analyzes the smallest networks, i.e., those with only a few chemical species or reactions. For these "smallest" networks, we completely answer the question of multistationarity and, in some cases, multistability, thereby extending related work of Boros. Our results highlight the role played by the Newton polytope of a network (the convex hull of the reactant vectors). Also, our work is motivated by recent results that explain how a given network's capacity for multistationarity arises from that of certain related networks which are typically smaller. Hence, we are interested in classifying small multistationary networks, and our work forms a first step in this direction. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1137/16M1069705 | SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS |
Keywords | Field | DocType |
chemical reaction network,mass-action kinetics,multiple steady states,bistability,deficiency,injectivity,Descartes' rule of signs,Newton polytope | Topology,Combinatorics,Polynomial,Pure mathematics,Convex hull,Polytope,Multistability,Mathematics | Journal |
Volume | Issue | ISSN |
16 | 2 | 1536-0040 |
Citations | PageRank | References |
3 | 0.47 | 13 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Badal Joshi | 1 | 15 | 2.30 |
| Anne Shiu | 2 | 87 | 14.47 |