Title
Sparse Autoencoder for Unsupervised Nucleus Detection and Representation in Histopathology Images.
Abstract
We propose a sparse Convolutional Autoencoder (CAE) for simultaneous nucleus detection and feature extraction in histopathology tissue images. Our CAE detects and encodes nuclei in image patches in tissue images into sparse feature maps that encode both the location and appearance of nuclei. A primary contribution of our work is the development of an unsupervised detection network by using the characteristics of histopathology image patches. The pretrained nucleus detection and feature extraction modules in our CAE can be fine-tuned for supervised learning in an end-to-end fashion. We evaluate our method on four datasets and achieve state-of-the-art results. In addition, we are able to achieve comparable performance with only 5% of the fully-supervised annotation cost.
Year
DOI
Venue
2019
10.1016/j.patcog.2018.09.007
Pattern Recognition
Keywords
DocType
Volume
Pathology image analysis,Convolutional neural network,Unsupervised learning,Semi-supervised learning
Journal
86
Issue
ISSN
Citations 
1
0031-3203
8
PageRank 
References 
Authors
0.51
44
7
Name
Order
Citations
PageRank
Le Hou1677.63
Vu Nguyen213418.35
Dimitris Samaras31740101.49
Tahsin M. Kurç41423149.77
Yi Gao580.51
Tianhao Zhao6121.60
Joel H. Saltz74046569.91