Name
Title | ||
|---|---|---|
Therapeutic indications and other use-case-driven updates in the drug ontology: anti-malarials, anti-hypertensives, opioid analgesics, and a large term request. |
Abstract | ||
|---|---|---|
A therapeutic indication of a drug product is represented as a therapeutic function in DrOn. Adverse effects of drug products, as well as other therapeutic uses for which the drug product was not designed are dispositions. Our work provides a framework for representing additional therapeutic indications, adverse effects, and uses of drug products beyond their design. Our work also validated our past modeling decisions for specific types of mechanisms of action, namely effects mediated via receptor and/or enzyme binding. DrOn is available at: http://purl.obolibrary.org/obo/dron.owl . A smaller version without NDCs is available at: http://purl.obolibrary.org/obo/dron/dron-lite.owl. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1186/s13326-017-0121-5 | J. Biomedical Semantics |
Keywords | Field | DocType |
Anti-hypertensive,Anti-malarial,Biomedical ontology,Disposition,Drug product,Function,Mechanism of action,Opioid analgesic,Patient centered outcomes research,Therapeutic indication | Ontology,Analgesics opioid,Anti-Hypertensives,Computer science,Opioid,Anti malarial,Comparative effectiveness research,Bioinformatics,Drug,Anti-malarials | Journal |
Volume | Issue | ISSN |
8 | 1 | 2041-1480 |
Citations | PageRank | References |
1 | 0.34 | 11 |
Authors | ||
10 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| William R. Hogan | 1 | 294 | 53.52 |
| Josh Hanna | 2 | 39 | 5.81 |
| Amanda Hicks | 3 | 11 | 4.50 |
| Samira Amirova | 4 | 1 | 0.34 |
| Baxter Bramblett | 5 | 1 | 0.34 |
| Matthew Diller | 6 | 1 | 0.34 |
| Rodel Enderez | 7 | 1 | 0.34 |
| Timothy Modzelewski | 8 | 1 | 0.34 |
| Mirela Vasconcelos | 9 | 1 | 0.34 |
| Chris Delcher | 10 | 1 | 1.69 |