Paper Info
Title
In Vivo Parametric T1 Maps Correlate with Structural and Molecular Characteristics of Focal Fibrosis.
Abstract
The purpose of this work was to use noninvasive in vivo MRI to characterize the substrate (i.e., known as gray zone, GZ) of ventricular arrhythmia, a major cause of sudden death. Our aim was to use a preclinical model of chronic infarction to study the structural and molecular characteristics of infarcted areas. For this, we related parametric T-1 maps with the density of collagen and gap junctions (Cx43 proteins) in patchy fibrosis in n = 6 swine with chronic infarction. Specifically, in vivo T-1 relaxation maps were calculated from 2D multi-contrast late enhancement (MCLE) MR images obtained at 1 x 1 x 5 mm resolution. Quantitative analysis and regression analysis demonstrated that the comparison between GZ and scar extent in MCLE to the corresponding areas identified in histology, yielded very good correlations in both cases (i.e., goodness of fit: R-2 = 0.89 for GZ, and 0.92 for dense scar, respectively). Furthermore, the gap junction Cx43 density was significantly reduced (i.e., by > 50%) in the ischemic GZ areas determined from MCLE. These novel results suggest that in vivo 2D parametric T-1 maps can be used to evaluate the biophysical properties of healing myocardium post-infarction, and to distinguish between the infarct categories (i.e., scar vs. GZ) with re-modelled structural and electrical characteristics.
Year
DOI
Venue
2017
10.1007/978-3-319-59448-4_2
Lecture Notes in Computer Science
Keywords
Field
DocType
Myocardial infarct,Cardiac MRI,T1 maps,Gray zone,Fibrosis,Gap junctions
Myocardial infarction,Fibrosis,Gap junction,Infarction,Focal fibrosis,In vivo,Parametric statistics,Medicine,Pathology
Conference
Volume
ISSN
Citations 
10263
0302-9743
0
PageRank 
References 
Authors
0.34
2
5
Name
Order
Citations
PageRank
Mihaela Pop18719.46
Samuel Oduneye2144.10
Li Zhang300.34
Susan Newbigging421.30
Graham A. Wright512325.09