Name
Title | ||
|---|---|---|
SMILE: A Novel Procedure for Subcellular Module Identification with Localization Expansion |
Abstract | ||
|---|---|---|
We propose a novel procedure, Subcellular Module Identification with Localization Expansion (SMILE), to identify super modules that consist of several subcellular modules performing specific biological functions among cell compartments. These super modules identified by SMILE are more functionally diverse and have been verified to be more associated with known protein complexes and biological pathways compared with the modules identified from the global protein interaction networks in both the ComPPI and InWeb_InBioMap protein interaction datasets. Our results reveal that subcellular localization is a principal feature of functional modules and offers important guidance in detecting biologically meaningful results. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1145/3107411.3110415 | BCB |
Keywords | Field | DocType |
Module identification,super module,protein interaction network,subcellular localization,cell compartment | Protein Interaction Networks,Computer science,Bioinformatics,Subcellular localization | Conference |
Volume | Issue | ISBN |
12 | 2 | 978-1-4503-4722-8 |
Citations | PageRank | References |
1 | 0.38 | 3 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Lixin Cheng | 1 | 24 | 2.80 |
| Pengfei Liu | 2 | 3 | 0.87 |
| Kwong-Sak Leung | 3 | 1887 | 205.58 |