Name
Title | ||
|---|---|---|
Network Disruption In The Preclinical Stages Of Alzheimer'S Disease: From Subjective Cognitive Decline To Mild Cognitive Impairment |
Abstract | ||
|---|---|---|
Introduction: Subjective Cognitive Decline (SCD) is a largely unknown state thought to represent a preclinical stage of Alzheimer's Disease (AD) previous to mild cognitive impairment (MCI). However, the course of network disruption in these stages is scarcely characterized. Methods: We employed resting state magnetoencephalography in the source space to calculate network smallworldness, clustering, modularity and transitivity. Nodal measures (clustering and node degree) as well as modular partitions were compared between groups. Results: The MCI group exhibited decreased smallworldness, clustering and transitivity and increased modularity in theta and beta bands. SCD showed similar but smaller changes in clustering and transitivity, while exhibiting alterations in the alpha band in opposite direction to those showed by MCI for modularity and transitivity. At the node level, MCI disrupted both clustering and nodal degree while SCD showed minor changes in the latter. Additionally, we observed an increase in modular partition variability in both SCD and MCI in theta and beta bands. Conclusion: SCD elders exhibit a significant network disruption, showing intermediate values between HC and MCI groups in multiple parameters. These results highlight the relevance of cognitive concerns in the clinical setting and suggest that network disorganization in AD could start in the preclinical stages before the onset of cognitive symptoms. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1142/S0129065717500411 | INTERNATIONAL JOURNAL OF NEURAL SYSTEMS |
Keywords | Field | DocType |
Alzheimer's disease, subjective cognitive decline, mild cognitive impairment, network, magnetoencephalography | Alpha (ethology),Disease,Neuroscience,Pattern recognition,Computer science,Resting state fMRI,Artificial intelligence,Beta (finance),Cluster analysis,Cognition,Magnetoencephalography,Cognitive decline | Journal |
Volume | Issue | ISSN |
27 | 8 | 0129-0657 |
Citations | PageRank | References |
5 | 0.40 | 20 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| D López-Sanz | 1 | 10 | 1.19 |
| Pilar Garcés | 2 | 11 | 1.83 |
| Blanca Álvarez | 3 | 5 | 0.40 |
| María Luisa Delgado-Losada | 4 | 5 | 0.40 |
| Ramón López-Higes | 5 | 5 | 0.40 |
| Fernando Maestú | 6 | 63 | 10.86 |