Paper Info
Title
Whole brain g-ratio mapping using myelin water imaging (MWI) and neurite orientation dispersion and density imaging (NODDI).
Abstract
MR g-ratio, which measures the ratio of the aggregate volume of axons to that of fibers in a voxel, is a potential biomarker for white matter microstructures. In this study, a new approach for acquiring an in-vivo whole human brain g-ratio map is proposed. To estimate the g-ratio, myelin volume fraction and axonal volume fraction are acquired using multi-echo gradient echo myelin water imaging (GRE-MWI) and neurite orientation dispersion and density imaging (NODDI), respectively. In order to translate myelin water fraction measured in GRE-MWI into myelin volume fraction, a new scaling procedure is proposed and validated. This scaling approach utilizes geometric measures of myelin structure and, therefore, provides robustness over previous methods. The resulting g-ratio map reveals an expected range of g-ratios (0.71–0.85 in major fiber bundles) with a small inter-subject coefficient of variance (less than 2%). Additionally, a few fiber bundles (e.g. cortico-spinal tract and optic radiation) show different constituents of myelin volume fraction and axonal volume fraction, indicating potentials to utilize the measures for deciphering fiber tracking.
Year
DOI
Venue
2018
10.1016/j.neuroimage.2017.09.053
NeuroImage
Keywords
Field
DocType
Myelin,Gradient-echo myelin water imaging (GRE-MWI),g-ratio,MRI,Diffusion,White matter microstructure
Biomedical engineering,Volume fraction,Voxel,Dispersion (optics),Neuroscience,White matter,Fiber,Psychology,Cognitive psychology,Neurite,Myelin,Optic radiation
Journal
Volume
ISSN
Citations 
182
1053-8119
4
PageRank 
References 
Authors
0.39
16
7
Name
Order
Citations
PageRank
Woojin Jung1273.33
Jingu Lee2222.18
Hyeong-Geol Shin382.16
Yoonho Nam4253.70
Hui Zhang537623.01
Se-Hong Oh662.12
Jongho Lee7746.15