Paper Info
Title
IMOTA: an interactive multi-omics tissue atlas for the analysis of human miRNA-target interactions.
Abstract
Web repositories for almost all 'omics' types have been generated-detailing the repertoire of representatives across different tissues or cell types. A logical next step is the combination of these valuable sources. With IMOTA (interactive multi omics tissue atlas), we developed a database that includes 23 725 relations between miRNAs and 23 tissues, 310 932 relations between mRNAs and the same tissues as well as 63 043 relations between proteins and the 23 tissues in Homo sapiens. IMOTA also contains data on tissue-specific interactions, e.g. information on 331 413 miRNAs and target gene pairs that are jointly expressed in the considered tissues. By using intuitive filter and visualization techniques, it is with minimal effort possible to answer various questions. These include rather general questions but also requests specific for genes, miRNAs or proteins. An example for a general task could be 'identify all miRNAs, genes and proteins in the lung that are highly expressed and where experimental evidence proves that the miRNAs target the genes'. An example for a specific request for a gene and a miRNA could for example be ' In which tissues is miR-34c and its target gene BCL2 expressed?'.
Year
DOI
Venue
2018
10.1093/nar/gkx701
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Gene,Biology,microRNA,Atlas (anatomy),Omics,Candidate Disease Gene,Computational biology,Genetics
Journal
46
Issue
ISSN
Citations 
D1
0305-1048
0
PageRank 
References 
Authors
0.34
7
7
Name
Order
Citations
PageRank
Valeria Palmieri100.34
Christina Backes222420.37
Nicole Ludwig3133.58
Tobias Fehlmann496.11
Fabian Kern533.55
Eckart Meese610814.50
Andreas Keller717321.19