Paper Info
Title
CR2Cancer: a database for chromatin regulators in human cancer.
Abstract
Chromatin regulators (CRs) can dynamically modulate chromatin architecture to epigenetically regulate gene expression in response to intrinsic and extrinsic signalling cues. Somatic alterations or mis-expression of CRs might reprogram the epigenomic landscape of chromatin, which in turn lead to a wide range of common diseases, notably cancer. Here, we present CR2Cancer, a comprehensive annotation and visualization database for CRs in human cancer constructed by high throughput data analysis and literature mining. We collected and integrated genomic, transcriptomic, proteomic, clinical and functional information for over 400 CRs across multiple cancer types. We also built diverse types of CR-associated relations, including cancer type dependent (CR-target andmiRNA-CR) and independent (protein-protein interaction and drug-target) ones. Furthermore, wemanually curated around 6000 items of aberrant molecular alterations and interactions of CRs in cancer development from 5007 publications. CR2Cancer provides a user-friendly web interface to conveniently browse, search and download data of interest. We believe that this database would become a valuable resource for cancer epigenetics investigation and potential clinical application. CR2Cancer is freely available at http://cis.hku.hk/CR2Cancer.
Year
DOI
Venue
2018
10.1093/nar/gkx877
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Genome,Biology,Gene expression,Chromatin remodeling,Genetics,Chromatin,Cancer,Mutation
Journal
46
Issue
ISSN
Citations 
D1
0305-1048
1
PageRank 
References 
Authors
0.36
20
10
Name
Order
Citations
PageRank
Beibei Ru1153.84
Jianlong Sun210.70
Yin Tong31118.16
Ching Ngar Wong410.70
Aditi Chandra510.36
Acacia Tsz So Tang610.36
Larry Ka Yue Chow710.36
Wai Lam Wun810.36
Zarina Levitskaya910.36
Jiangwen Zhang1011.04