Paper Info
Title
TADB 2.0: an updated database of bacterial type II toxin-antitoxin loci.
Abstract
TADB2.0 (http://bioinfo-mml.sjtu.edu.cn/TADB2/) is an updated database that provides comprehensive information about bacterial type II toxin-antitoxin (TA) loci. Compared with the previous version, the database refined and the new data schema is employed. With the aid of text mining and manual curation, it recorded 6193 type II TA loci in 870 replicons of bacteria and archaea, including 105 experimentally validated TA loci. In addition, the newly developed tool TAfinder combines the homolog searches and the operon structure detection, allowing the prediction for type II TA pairs in bacterial genome sequences. It also helps to investigate the genomic context of predicted TA loci for putative virulence factors, antimicrobial resistance determinants and mobile genetic elements via alignments to the specific public databases. Additionally, the module TAfinder-Compare allows comparing the presence of the given TA loci across the close relative genomes. With the recent updates, TADB2.0 might provide better support for understanding the important roles of type II TA systems in the prokaryotic life activities.
Year
DOI
Venue
2018
10.1093/nar/gkx1033
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Antitoxin,Toxin,Biology,Locus (genetics),Genetics
Journal
46
Issue
ISSN
Citations 
D1
0305-1048
2
PageRank 
References 
Authors
0.39
4
8
Name
Order
Citations
PageRank
Yingzhou Xie131.10
Yiqing Wei280.93
Yue Shen3196.48
Xiaobin Li497.97
Hao Zhou520.39
Cui Tai6304.19
Zixin Deng7395.74
Hong-Yu Ou8395.69