Paper Info
Title
Phenotypic stability and plasticity in GMP-derived cells as determined by their underlying regulatory network.
Abstract
Motivation: Blood cell formation has been recognized as a suitable system to study celular differentiation mainly because of its experimental accessibility, and because it shows characteristics such as hierarchical and gradual bifurcated patterns of commitment, which are present in several developmental processes. Although hematopoiesis has been extensively studied and there is a wealth of molecular and cellular data about it, it is not clear how the underlying molecular regulatory networks define or restrict cellular differentiation processes. Here, we infer the molecular regulatory network that controls the differentiation of a blood cell subpopulation derived from the granulocyte-monocyte precursor (GMP), comprising monocytes, neutrophils, eosinophils, basophils and mast cells. Results: We integrate published qualitative experimental data into a model to describe temporal expression patterns observed in GMP-derived cells. The model is implemented as a Boolean network, and its dynamical behavior is studied. Steady states of the network can be clearly identified with the expression profiles of monocytes, mast cells, neutrophils, basophils, and eosinophils, under wild-type and mutant backgrounds.
Year
DOI
Venue
2018
10.1093/bioinformatics/btx736
BIOINFORMATICS
Field
DocType
Volume
Phenotype,Biology,Bioinformatics,Computational biology,Plasticity
Journal
34
Issue
ISSN
Citations 
7
1367-4803
0
PageRank 
References 
Authors
0.34
3
2
Name
Order
Citations
PageRank
Carlos Ramírez100.34
luis mendoza227125.94