Name
Title | ||
|---|---|---|
Real-Time Model-Based Control Of Afterload For In Vitro Cardiac Tissue Experimentation |
Abstract | ||
|---|---|---|
The performance of mechanical work by isolated cardiac muscle samples has typically been studied by subjecting their tissues to an isotonic shortening protocol, which results in "flat-topped" work-loop profiles. In order to better replicate the forces experienced by these tissues in vivo, we have developed a system for imposing a model-based, time-varying, load on isolated cardiac tissue preparations. A model of systemic afterload was developed from the combination of a Windkessel-type model of vascular fluid impedance, and the Laplace law of the heart, and encoded into a hardware-based control system. The model-predicted length change was then imposed on an isolated cardiac trabecula in a work-loop calorimeter, giving rise to force-length work-loops that more closely resemble those experienced by these tissues in vivo. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1109/EMBC.2017.8037067 | 2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) |
Field | DocType | Volume |
Hemodynamics,Biomedical engineering,Real time model,Computer science,In vitro,Cardiac muscle,Isotonic,In vivo,Afterload | Conference | 2017 |
ISSN | Citations | PageRank |
1094-687X | 0 | 0.34 |
References | Authors | |
1 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Amy S. Garrett | 1 | 0 | 0.68 |
| Toan Pham | 2 | 0 | 1.35 |
| Denis S Loiselle | 3 | 2 | 2.94 |
| June-Chiew Han | 4 | 2 | 2.94 |
| Andrew J. Taberner | 5 | 28 | 10.59 |