Paper Info
Title
Resting-State Brain Correlates Of Cardiovascular Complexity
Abstract
While estimates of complex heartbeat dynamics have provided effective prognostic and diagnostic markers for a wide range of pathologies, brain correlates of complex cardiac measures in general and of complex sympatho-vagal dynamics in particular are still unknown. In this study we combine resting state functional Magnetic Resonance Imaging (fMRI) and physiological signal acquisition from 34 healthy subjects selected from the Human Connectome Project (HCP) repository with inhomogeneous point-process approximate and sample heartbeat entropy measures (ipApEn and ipSampEn) to investigate brain areas involved in complex cardiovascular control. Our results show that activity in the Temporal Gyrus, Frontal Orbital Cortex, Temporal Fusiform and Opercular cortices, Planum Temporale, and Paracingulate cortex are negatively correlated with ipApEn dynamics. Activity in the same cortical areas as well as in the Temporal Fusiform cortex are negatively correlated with ipSampEn dynamics. No significant positive correlations were found. These pioneering results suggest that cardiovascular complexity at rest is linked to a few specific cortical brain structures, including crucial areas connected with parasympathetic outflow. This corroborates the hypothesis of a multidimensional central network which controls nonlinear cardiac dynamics under a predominantly vagally-driven tone.
Year
DOI
Venue
2017
10.1109/EMBC.2017.8037566
2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
Field
DocType
Volume
Cortex (botany),Neuroscience,Heartbeat,Planum temporale,Human Connectome Project,Functional magnetic resonance imaging,Frontal orbital cortex,Resting state fMRI,Psychology,Gyrus
Conference
2017
ISSN
Citations 
PageRank 
1094-687X
0
0.34
References 
Authors
11
7
Name
Order
Citations
PageRank
Gaetano Valenza131448.21
Andrea Duggento2117.37
Luca Passamonti34311.28
Diciotti, S.4303.13
carlo tessa5122.98
nicola toschi63615.57
Riccardo Barbieri746070.50