Title
Pathological Pulmonary Lobe Segmentation From Ct Images Using Progressive Holistically Nested Neural Networks And Random Walker
Abstract
Automatic pathological pulmonary lobe segmentation(PPLS) enables regional analyses of lung disease, a clinically important capability. Due to often incomplete lobe boundaries, PPLS is difficult even for experts, and most prior art requires inference from contextual information. To address this, we propose a novel PPLS method that couples deep learning with the random walker (RW) algorithm. We first employ the recent progressive holistically-nested network (P-HNN) model to identify potential lobar boundaries, then generate final segmentations using a RW that is seeded and weighted by the P-HNN output. We are the first to apply deep learning to PPLS. The advantages are independence from prior airway/ vessel segmentations, increased robustness in diseased lungs, and methodological simplicity that does not sacrifice accuracy. Our method posts a high mean Jaccard score of 0.888 +/- 0.164 on a held-out set of 154 CT scans from lung-disease patients, while also significantly (p<0.001) outperforming a state-of-the-art method.
Year
DOI
Venue
2017
10.1007/978-3-319-67558-9_23
DEEP LEARNING IN MEDICAL IMAGE ANALYSIS AND MULTIMODAL LEARNING FOR CLINICAL DECISION SUPPORT
Keywords
DocType
Volume
Lung lobe segmentation, CT, Holistically nested neural network, Fissure, Random walker
Journal
10553
ISSN
Citations 
PageRank 
0302-9743
1
0.34
References 
Authors
2
5
Name
Order
Citations
PageRank
Kevin George1191.42
Adam P. Harrison210117.06
Dakai Jin35311.67
Ziyue Xu459735.50
Daniel J Mollura561430.82