Paper Info
Title
Spatiotemporal Analysis of Structural Changes of the Lamina Cribrosa.
Abstract
Glaucoma, a progressive and degenerative disease of the optic nerve, is the second leading cause of blindness worldwide. Mechanical deformation of the lamina cribrosa (LC) under high intraocular pressure (IOP) can lead to axonal death of optic nerve fibers. To explore the effect of pressure on the LC, we utilize an experimental setup where longitudinal 3D optical coherence tomography (OCT) images are acquired at different levels of IOP administered via a well-controlled external force. Structural changes are measured via image deformations which map all observed images simultaneously into a common coordinate space. These deformations encode local patterns of structural and volume change across the image sequence, resulting in quantification of the spatiotemporal deformation pattern of the LC due to variation of pressure. We also describe a 3D segmentation algorithm to restrict our deformation analysis separately to the beams or pores of the LC. A single case study demonstrates the potential of the proposed methodology for non-invasive in-vivo analysis of LC dynamics in individual subjects.
Year
DOI
Venue
2017
10.1007/978-3-319-67561-9_21
Lecture Notes in Computer Science
Keywords
Field
DocType
OCT,Lamina cribrosa,Spatiotemporal analysis,Glaucoma
Biomedical engineering,Computer vision,Glaucoma,Optical coherence tomography,Segmentation,Computer science,Artificial intelligence,Deformation (mechanics),Spatiotemporal Analysis,Blindness,Lamina,Optic nerve
Conference
Volume
ISSN
Citations 
10554
0302-9743
1
PageRank 
References 
Authors
0.43
1
6
Name
Order
Citations
PageRank
Charly Girot110.77
ishikawa251530.86
Fishbaugh James3599.48
Gadi Wollstein421.13
Joel S Schuman5638.75
Guido Gerig64795540.21