Name
Title | ||
|---|---|---|
EliIE: An open-source information extraction system for clinical trial eligibility criteria. |
Abstract | ||
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To develop an open-source information extraction system called Eligibility Criteria Information Extraction (EliIE) for parsing and formalizing free-text clinical research eligibility criteria (EC) following Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) version 5.0. EliIE parses EC in 4 steps: (1) clinical entity and attribute recognition, (2) negation detection, (3) relation extraction, and (4) concept normalization and output structuring. Informaticians and domain experts were recruited to design an annotation guideline and generate a training corpus of annotated EC for 230 Alzheimer's clinical trials, which were represented as queries against the OMOP CDM and included 8008 entities, 3550 attributes, and 3529 relations. A sequence labeling-based method was developed for automatic entity and attribute recognition. Negation detection was supported by NegEx and a set of predefined rules. Relation extraction was achieved by a support vector machine classifier. We further performed terminology-based concept normalization and output structuring. In task-specific evaluations, the best F1 score for entity recognition was 0.79, and for relation extraction was 0.89. The accuracy of negation detection was 0.94. The overall accuracy for query formalization was 0.71 in an end-to-end evaluation. This study presents EliIE, an OMOP CDM-based information extraction system for automatic structuring and formalization of free-text EC. According to our evaluation, machine learning-based EliIE outperforms existing systems and shows promise to improve. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1093/jamia/ocx019 | JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION |
Keywords | Field | DocType |
natural language processing,machine learning,clinical trials,patient selection,common data model,named entity recognition | Eligibility Determination,Information retrieval,Knowledge management,Clinical trial,Information extraction,Medicine | Journal |
Volume | Issue | ISSN |
24 | 6 | 1067-5027 |
Citations | PageRank | References |
5 | 0.53 | 35 |
Authors | ||
7 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Tian Kang | 1 | 33 | 6.00 |
| Shaodian ZHANG | 2 | 167 | 12.49 |
| Youlan Tang | 3 | 5 | 0.53 |
| Gregory William Hruby | 4 | 7 | 3.61 |
| Alexander Rusanov | 5 | 40 | 3.44 |
| Noémie Elhadad | 6 | 6 | 1.22 |
| Chunhua Weng | 7 | 547 | 75.69 |