Paper Info
Title
Leveraging putative enhancer-promoter interactions to investigate two-way epistasis in Type 2 Diabetes GWAS.
Abstract
We utilized evidence for enhancer-promoter interactions from functional genomics data in order to build biological filters to narrow down the search space for two-way Single Nucleotide Polymorphism (SNP) interactions in Type 2 Diabetes (T2D) Genome Wide Association Studies (GWAS). This has led us to the identification of a reproducible statistically significant SNP pair associated with T2D. As more functional genomics data are being generated that can help identify potentially interacting enhancer-promoter pairs in larger collection of tissues/cells, this approach has implications for investigation of epistasis from GWAS in general.
Year
Venue
Keywords
2018
Biocomputing-Pacific Symposium on Biocomputing
epistasis,GWAS,type 2 diabetes,enhancers,genetic encoding
Field
DocType
Volume
Biology,Epistasis,Type 2 diabetes,Genome-wide association study,Functional genomics,Genomics,Single-nucleotide polymorphism,Bioinformatics,Enhancer,Genetics,SNP
Conference
23
ISSN
Citations 
PageRank 
2335-6936
0
0.34
References 
Authors
0
5
Name
Order
Citations
PageRank
Elisabetta Manduchi14913.37
Alessandra Chesi200.34
Molly A Hall331.75
Struan F A Grant450.98
Jason H. Moore51223159.43