Paper Info
Title
Functional Protein-Protein Interaction Networks Regulated By 6-Gingerol Targeting Stomach And Small Intestine
Abstract
Ginger is widely used as a spice and traditional Chinese medicine achieving warming interior for dispelling cold during its long time clinical observations and practices. However, its mechanism is still obscure. In this study, interior is restricted to stomach and small intestine. 6-gingerol, ginger's quality control and main bio-active chemical compound, is chosen to represent ginger. Started with biomarkers reported in literatures. Functional protein-protein interactions (FPPI) from biomarkers to proteins expressed in stomach and small intestine were filtered out. These FPPIs form networks regulated by 6-gingerol targeting interior. Further enrichment analysis highlighted biological processes concentrated on metabolic regulations for more energy generation, metal ion transmembrane transporter activity for better digest, more blood flow volume for nutrient and warmth, and cell cycle regulation to prevent canceration. Taken together, ginger's warming up interior for cold expelling is elaborated via bioinformatics analysis on 6-gingerol.
Year
Venue
Keywords
2017
2017 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)
6-gingerol, biological process, functional protein-protein interaction, warming interior, dispelling cold
Field
DocType
ISSN
Protein protein interaction network,Stomach,Small intestine,6-gingerol,Computer science,Cell biology,Bioinformatics analysis,Metal ion transmembrane transporter activity,Bioinformatics,Lipidomics,Cell cycle
Conference
2156-1125
Citations 
PageRank 
References 
0
0.34
0
Authors
4
Name
Order
Citations
PageRank
Guang Zheng102.70
Yun Yang2769.80
Chengqiang Li300.68
Hongtao Guo400.68