Paper Info
Title
A task-related and resting state realistic fMRI simulator for fMRI data validation.
Abstract
After more than 25 years of published functional magnetic resonance imaging (fMRI) studies, careful scrutiny reveals that most of the reported results lack fully decisive validation. The complex nature of fMRI data generation and acquisition results in unavoidable uncertainties in the true estimation and interpretation of both task-related activation maps and resting state functional connectivity networks, despite the use of various statistical data analysis methodologies. The goal of developing the proposed STANCE (Spontaneous and Task-related Activation of Neuronally Correlated Events) simulator is to generate realistic task-related and/or resting-state 4D blood oxygenation level dependent (BOLD) signals, given the experimental paradigm and scan protocol, by using digital phantoms of twenty normal brains available from BrainWeb (http://brainweb.bic.mni.mcgill.ca/brainweb/). The proposed simulator will include estimated system and modelled physiological noise as well as motion to serve as a reference to measured brain activities. In its current form, STANCE is a MATLAB toolbox with command line functions serving as an open-source add-on to SPM8 (http://www.fil.ion.ucl.ac.uk/spm/software/spm8/). The STANCE simulator has been designed in a modular framework so that the hemodynamic response (HR) and various noise models can be iteratively improved to include evolving knowledge about such models.
Year
DOI
Venue
2017
10.1117/12.2254777
Proceedings of SPIE
Keywords
Field
DocType
Simulation,modeled ground-truth,fMRI,resting state fMRI,correlation,hemodynamic response,physiological noise
Data validation,MATLAB,Functional magnetic resonance imaging,Simulation,Computer science,Resting state fMRI,Software,Modular design,Communication noise,Test data generation
Conference
Volume
ISSN
Citations 
10133
0277-786X
0
PageRank 
References 
Authors
0.34
14
4
Name
Order
Citations
PageRank
Jason E. Hill112.09
Xiangyu Liu25114.10
Brian Nutter310120.24
Sunanda Mitra425445.17