Title
A whole brain atlas with sub-parcellation of cortical gyri using resting fMRI.
Abstract
The new hybrid-BCI-DNI atlas is a high-resolution MPRAGE, single-subject atlas, constructed using both anatomical and functional information to guide the parcellation of the cerebral cortex. Anatomical labeling was performed manually on coronal single-slice images guided by sulcal and gyral landmarks to generate the original (non-hybrid) BCI-DNI atlas. Functional sub-parcellations of the gyral ROIs were then generated from 40 minimally preprocessed resting fMRI datasets from the HCP database. Gyral ROIs were transferred from the BCI-DNI atlas to the 40 subjects using the HCP grayordinate space as a reference. For each subject, each gyral ROI was subdivided using the fMRI data by applying spectral clustering to a similarity matrix computed from the fMRI time-series correlations between each vertex pair. The sub-parcellations were then transferred back to the original cortical mesh to create the subparcellated hBCI-DNI atlas with a total of 67 cortical regions per hemisphere. To assess the stability of the gyral subdivisons, a separate set of 60 HCP datasets were processed as follows: 1) coregistration of the structural scans to the hBCI-DNI atlas; 2) coregistration of the anatomical BCI-DNI atlas without functional subdivisions, followed by sub-parcellation of each subject's resting fMRI data as described above. We then computed consistency between the anatomically-driven delineation of each gyral subdivision and that obtained per subject using individual fMRI data. The gyral sub-parcellations generated by atlas-based registration show variable but generally good overlap of the confidence intervals with the resting fMRI-based subdivisions. These consistency measures will provide a quantitative measure of reliability of each subdivision to users of the atlas.
Year
DOI
Venue
2017
10.1117/12.2254681
Proceedings of SPIE
Keywords
Field
DocType
Brain,Atlas,MRI,fMRI,Parcellation
Computer vision,Spectral clustering,Brain atlas,Functional magnetic resonance imaging,Computer science,Atlas (anatomy),Artificial intelligence,Similarity matrix
Conference
Volume
ISSN
Citations 
10133
0277-786X
0
PageRank 
References 
Authors
0.34
5
9
Name
Order
Citations
PageRank
Anand Joshi123523.06
Soyoung Choi2172.43
Gaurav Sonkar300.34
Minqi Chong491.95
Jorge Gonzalez-Martinez5226.07
Dileep Nair610.69
David W. Shattuck772256.26
H Damasio814614.24
Richard M Leahy91768295.29