Paper Info
Title
Can brain state be manipulated to emphasize individual differences in functional connectivity?
Abstract
While neuroimaging studies typically collapse data from many subjects, brain functional organization varies between individuals, and characterizing this variability is crucial for relating brain activity to behavioral phenotypes. Rest has become the default state for probing individual differences, chiefly because it is easy to acquire and a supposed neutral backdrop. However, the assumption that rest is the optimal condition for individual differences research is largely untested. In fact, other brain states may afford a better ratio of within- to between-subject variability, facilitating biomarker discovery. Depending on the trait or behavior under study, certain tasks may bring out meaningful idiosyncrasies across subjects, essentially enhancing the individual signal in networks of interest beyond what can be measured at rest. Here, we review theoretical considerations and existing work on how brain state influences individual differences in functional connectivity, present some preliminary analyses of within- and between-subject variability across conditions using data from the Human Connectome Project, and outline questions for future study.
Year
DOI
Venue
2017
10.1016/j.neuroimage.2017.03.064
NeuroImage
Keywords
Field
DocType
fMRI,Functional connectivity,Individual differences,Brain state,Scan condition,Resting state,Task,Human Connectome Project
Brain mapping,Developmental psychology,Human Connectome Project,Connectome,Trait,Resting state fMRI,Cognitive psychology,Psychology,Brain activity and meditation,Neuroimaging
Journal
Volume
ISSN
Citations 
160
1053-8119
28
PageRank 
References 
Authors
1.12
28
6
Name
Order
Citations
PageRank
Emily S Finn11196.00
Dustin Scheinost228722.17
Daniel M. Finn3281.12
Xilin Shen427814.18
Xenophon Papademetris551648.77
R Todd Constable684877.34