Title
Lung lesion detection in FDG-PET/CT with Gaussian process regression.
Abstract
In this study, we propose a novel method of lung lesion detection in FDG-PET/CT volumes without labeling lesions. In our method,the probability distribution over normal standardized uptake values (SUVs) is estimated from the features extracted from the corresponding volume of interest (VOI) in the CT volume, which include gradient-based and texture-based features. To estimate the distribution, we use Gaussian process regression with an automatic relevance determination kernel, which provides the relevance of feature values to estimation. Our SUV is judged as normal or abnormal by comparison with the estimated SUV distribution. According to the validation using 28 FDG-PET/CT volumes with 34 lung lesions, the sensitivity of proposed method at 5.0 false positives per case was 81.9%.
Year
DOI
Venue
2017
10.1117/12.2255588
Proceedings of SPIE
Keywords
Field
DocType
FDG-PET/CT,computer-assisted detection,distribution estimation,Gaussian process regression,anomaly detection
Nuclear medicine,Kriging,Computer vision,Anomaly detection,Volume of interest,Lung lesion,PET-CT,Lesion,Probability distribution,Artificial intelligence,Physics,False positive paradox
Conference
Volume
ISSN
Citations 
10134
0277-786X
0
PageRank 
References 
Authors
0.34
4
7
Name
Order
Citations
PageRank
Ryosuke Kamesawa100.34
Issei Sato233141.59
Shouhei Hanaoka3267.56
Nomura, Y.4319.51
Mitsutaka Nemoto5468.42
Naoto Hayashi6206.38
Masashi Sugiyama73353264.24