Title
Automated assessment of imaging biomarkers for the PanCan lung cancer risk prediction model with validation on NLST data.
Abstract
The imaging biomarkers EmphysemaPresence and NoduleSpiculation are crucial inputs for most models aiming to predict the risk of indeterminate pulmonary nodules detected at CT screening. To increase reproducibility and to accelerate screening workflow it is desirable to assess these biomarkers automatically. Validation on NLST images indicates that standard histogram measures are not sufficient to assess EmphysemaPresence in screenees. However, automatic scoring of bulla-resembling low attenuation areas can achieve agreement with experts with close to 80% sensitivity and specificity. NoduleSpiculation can be automatically assessed with similar accuracy. We find a dedicated spiculi tracing score to slightly outperform generic combinations of texture features with classifiers.
Year
DOI
Venue
2017
10.1117/12.2253905
Proceedings of SPIE
Field
DocType
Volume
Lung cancer,Computer vision,Reproducibility,Histogram,Lung cancer screening,Pattern recognition,Computer-aided diagnosis,Biomarker (medicine),Artificial intelligence,Workflow,Tracing,Physics
Conference
10134
ISSN
Citations 
PageRank 
0277-786X
1
0.37
References 
Authors
3
7
Name
Order
Citations
PageRank
Rafael Wiemker124429.84
Merlijn Sevenster29813.33
Heber MacMahon320231.61
Feng Li451.59
sandeep dalal531.48
Amir M. Tahmasebi6609.66
Tobias Klinder721622.50