Title
Fusion of multi-parametric MRI and temporal ultrasound for characterization of prostate cancer: in vivo feasibility study.
Abstract
Recently, multi-parametric Magnetic Resonance Imaging (mp-MRI) has been used to improve the sensitivity of detecting high-risk prostate cancer (PCa). Prior to biopsy, primary and secondary cancer lesions are identified on mp-MRI. The lesions are then targeted using TRUS guidance. In this paper, for the first time, we present a fused mp-MRI-temporal-ultrasound framework for characterization of PCa, in vivo. Cancer classification results obtained using temporal ultrasound are fused with those achieved using consolidated mp-MRI maps determined by multiple observers. We verify the outcome of our study using histopathology following deformable registration of ultrasound and histology images. Fusion of temporal ultrasound and mp-MRI for characterization of the PCa results in an area under the receiver operating characteristic curve (AUC) of 0.86 for cancerous regions with Gleason scores (GSs)>= 3+3, and AUC of 0.89 for those with GSs >= 3+4.
Year
DOI
Venue
2016
10.1117/12.2217205
Proceedings of SPIE
Keywords
Field
DocType
Temporal ultrasound,multi-parametric MRI,ultrasound-MRI fusion,prostate cancer
Nuclear medicine,Receiver operating characteristic,Histopathology,Biopsy,In vivo,Artificial intelligence,Prostate cancer,Computer vision,Medical physics,Cancer,Physics,Magnetic resonance imaging,Ultrasound
Conference
Volume
ISSN
Citations 
9785
0277-786X
0
PageRank 
References 
Authors
0.34
0
19