Paper Info
Title
RegulatorTrail: a web service for the identification of key transcriptional regulators.
Abstract
Transcriptional regulators such as transcription factors and chromatin modifiers play a central role in most biological processes. Alterations in their activities have been observed in many diseases, e.g. cancer. Hence, it is of utmost importance to evaluate and assess the effects of transcriptional regulators on natural and pathogenic processes. Here, we present RegulatorTrail, a web service that provides rich functionality for the identification and prioritization of key transcriptional regulators that have a strong impact on, e.g. pathological processes. RegulatorTrail offers eight methods that use regulator binding information in combination with transcriptomic or epigenomic data to infer the most influential regulators. Our web service not only provides an intuitive web interface, but also a well-documented RESTful API that allows for a straightforward integration into third-party workflows. The presented case studies highlight the capabilities of our web service and demonstrate its potential for the identification of influential regulators: we successfully identified regulators that might explain the increased malignancy in metastatic melanoma compared to primary tumors, as well as important regulators in macrophages. RegulatorTrail is freely accessible at: https://regulatortrail.bioinf.uni-sb.de/.
Year
DOI
Venue
2017
10.1093/nar/gkx350
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Biology,Computational biology,Web service,Chromatin,Genetics,Workflow,Transcription factor
Journal
45
Issue
ISSN
Citations 
W1
0305-1048
1
PageRank 
References 
Authors
0.36
19
10
Name
Order
Citations
PageRank
Tim Kehl1134.78
Lara Schneider262.16
Florian Schmidt326834.52
Daniel Stöckel461.15
Nico Gerstner511.71
Christina Backes622420.37
Eckart Meese710814.50
Andreas Keller891.69
Marcel H Schulz924024.03
Hans-peter Lenhof1061564.08