Paper Info
Title
GalaxyHomomer: a web server for protein homo-oligomer structure prediction from a monomer sequence or structure.
Abstract
Homo-oligomerization of proteins is abundant in nature, and is often intimately related with the physiological functions of proteins, such as in metabolism, signal transduction or immunity. Information on the homo-oligomer structure is therefore important to obtain a molecular-level understanding of protein functions and their regulation. Currently available web servers predict protein homooligomer structures either by template-based modeling using homo-oligomer templates selected from the protein structure database or by ab initio docking of monomer structures resolved by experiment or predicted by computation. The GalaxyHomomer server, freely accessible at http://galaxy.seoklab.org/homomer, carries out template-based modeling, ab initio docking or both depending on the availability of proper oligomer templates. It also incorporates recently developed model refinement methods that can consistently improve model quality. Moreover, the server provides additional options that can be chosen by the user depending on the availability of information on the monomer structure, oligomeric state and locations of unreliable/flexible loops or termini. The performance of the server was better than or comparable to that of other available methods when tested on benchmark sets and in a recent CASP performed in a blind fashion.
Year
DOI
Venue
2017
10.1093/nar/gkx246
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Oligomer,Biology,Template,Computational biology,Bioinformatics,Genetics,Monomer,Web server,Protein structure
Journal
45
Issue
ISSN
Citations 
W1
0305-1048
2
PageRank 
References 
Authors
0.37
13
5
Name
Order
Citations
PageRank
Minkyung Baek121.38
Taeyong Park221.05
Lim Heo3474.56
Chiwook Park420.37
Chaok Seok516315.89