Name
Title | ||
|---|---|---|
A comprehensive analysis on preservation patterns of gene co-expression networks during Alzheimer's disease progression. |
Abstract | ||
|---|---|---|
In this article, we have extensively studied the preservation patterns of co-expressed modules in six distinct brain regions affected in AD. Some modules are emerged as the most preserved while some others are detected as perturbed between a pair of brain regions. Further investigation on the topological properties of preserved and non-preserved modules reveals a substantial association amongst "betweenness centrality" and "degree" of the involved genes. Our findings may render a deeper realization of the preservation characteristics of gene expression patterns in discrete brain regions affected by AD. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1186/s12859-017-1946-8 | BMC Bioinformatics |
Keywords | Field | DocType |
Gene co-expression networks,Hierarchical clustering,Module preservation measures,Rank aggregation | Disease,Neuroscience,Gene,Alzheimer's disease,Biology,Transcriptome,Pathogenesis,Gene regulatory network,Genetics,Gene expression profiling,DNA microarray | Journal |
Volume | Issue | ISSN |
18 | 1 | 1471-2105 |
Citations | PageRank | References |
0 | 0.34 | 14 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Sumanta Ray | 1 | 26 | 4.39 |
| Sk Md Mosaddek Hossain | 2 | 1 | 0.70 |
| Lutfunnesa Khatun | 3 | 0 | 0.34 |
| Anirban Mukhopadhyay | 4 | 711 | 50.07 |