Title
On the application of statistical learning approaches to construct inverse probability weights in marginal structural Cox models: Hedging against weight-model misspecification.
Abstract
The marginal structural Cox model (MSCM) estimates can be highly sensitive to weight-model misspecification. We assess the performance of various popular statistical learners, such as LASSO, support vector machines, CART, bagged CART, and boosted CART, in estimating MSCM weights. When weight-models are misspecified, we find that the weights computed from boosted CART generally lead to less MSE and better coverage for the MSCM estimates. This study is motivated by the investigation of the impact of beta-interferon treatment on disability progression in subjects with multiple sclerosis from British Columbia, Canada (1995-2008).
Year
DOI
Venue
2017
10.1080/03610918.2016.1248574
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
Keywords
Field
DocType
Causal inference,Inverse probability weighting,Machine learning,Marginal structural models,Model misspecification,Multiple sclerosis
Econometrics,Inverse probability weighting,Causal inference,Proportional hazards model,Cart,Lasso (statistics),Support vector machine,Marginal structural model,Statistics,Inverse probability,Mathematics
Journal
Volume
Issue
ISSN
46
10
0361-0918
Citations 
PageRank 
References 
1
0.35
5
Authors
5
Name
Order
Citations
PageRank
Mohammad Ehsanul Karim110.69
John Petkau210.35
Paul Gustafson310.35
Helen Tremlett410.35
The Beams Study Group510.35