Title
Histogram analysis of T2*-based pharmacokinetic imaging in cerebral glioma grading.
Abstract
•A histogram analysis of the Ktrans permeability imaging derived from the T2* DSC-PW-MRI through entire tumor volume was proposed.•Histogram parameters of Ktrans measurements exhibited significant results for high- and low-grade glioma differentiation and correlations with glioma grades.•Ktrans reflects vascular permeability, supporting that angiogenesis with BBB permeability breakdown is increased in a high-grade tumor compared with that in a low-grade tumor.•Histogram metrics of vascular permeability and blood volume in the T2* DSC-PW-MRI measurements exhibit a reliable correlation with tumor grade on the basis of the heterogeneity of the entire tumor volume.
Year
DOI
Venue
2018
10.1016/j.cmpb.2017.11.011
Computer Methods and Programs in Biomedicine
Keywords
Field
DocType
Permeability imaging,Tumor grading,Cerebral glioma,Histogram analysis
Nuclear medicine,Computer vision,Histogram,Vascular permeability,Computer science,Pharmacokinetics,Glioma,Blood plasma volume,Artificial intelligence,Tumor Grading,Magnetic resonance imaging
Journal
Volume
ISSN
Citations 
155
0169-2607
0
PageRank 
References 
Authors
0.34
0
9
Name
Order
Citations
PageRank
Hua-shan Liu173.22
Shih-Wei Chiang200.34
Hsiao-Wen Chung351.19
Ping-Huei Tsai400.34
Fei-Ting Hsu500.34
Nai-Yu Cho600.34
Chao-Ying Wang700.34
Ming-Chung Chou8462.79
Cheng-Yu Chen96810.76