Name
Title | ||
|---|---|---|
Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors. |
Abstract | ||
|---|---|---|
The proteins involved in the autophagy (Atg) pathway have recently been considered promising targets for the development of new antimalarial drugs. In particular, inhibitors of the protein-protein interaction (PPI) between Atg3 and Atg8 of Plasmodium falciparum retarded the blood- and liver-stages of parasite growth. In this paper, we used computational techniques to design a new class of peptidomimetics mimicking the Atg3 interaction motif, which were then synthesized by click-chemistry. Surface plasmon resonance has been employed to measure the ability of these compounds to inhibit the Atg3-Atg8 reciprocal protein-protein interaction. Moreover, P. falciparum growth inhibition in red blood cell cultures was evaluated as well as the cyto-toxicity of the compounds. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1007/s10822-018-0102-5 | JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN |
Keywords | Field | DocType |
Malaria,Autophagy,Atg8 inhibitors,Docking,PPI inhibitors,Peptidomimetics,1,2,3-Triazole | Plasma protein binding,Protein–protein interaction,ATG8,Docking (dog),Biochemistry,Chemistry,Plasmodium falciparum,Growth inhibition,Structure–activity relationship,Bioinformatics,Peptidomimetic | Journal |
Volume | Issue | ISSN |
32.0 | 3.0 | 0920-654X |
Citations | PageRank | References |
0 | 0.34 | 2 |
Authors | ||
10 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Stefania Villa | 1 | 0 | 0.34 |
| Laura Legnani | 2 | 1 | 0.78 |
| diego roberto colombo dias | 3 | 8 | 4.02 |
| Arianna Gelain | 4 | 0 | 0.34 |
| Carmen Lammi | 5 | 0 | 0.34 |
| Daniele Bongiorno | 6 | 0 | 0.34 |
| Denise P. Ilboudo | 7 | 0 | 0.34 |
| Kellen E. McGee | 8 | 0 | 0.34 |
| Jürgen Bosch | 9 | 0 | 0.34 |
| Giovanni Grazioso | 10 | 12 | 3.77 |