Paper Info
Title
Modeling Contact Inhibition of Locomotion of Colliding Cells Migrating on Micropatterned Substrates.
Abstract
In cancer metastasis, embryonic development, and wound healing, cells can coordinate their motion, leading to collective motility. To characterize these cell-cell interactions, which include contact inhibition of locomotion (CIL), micropatterned substrates are often used to restrict cell migration to linear, quasi-one-dimensional paths. In these assays, collisions between polarized cells occur frequently with only a few possible outcomes, such as cells reversing direction, sticking to one another, or walking past one another. Using a computational phase field model of collective cell motility that includes the mechanics of cell shape and a minimal chemical model for CIL, we are able to reproduce all cases seen in two-cell collisions. A subtle balance between the internal cell polarization, CIL and cell-cell adhesion governs the collision outcome. We identify the parameters that control transitions between the different cases, including cell-cell adhesion, propulsion strength, and the rates of CIL. These parameters suggest hypotheses for why different cell types have different collision behavior and the effect of interventions that modulate collision outcomes. To reproduce the heterogeneity in cell-cell collision outcomes observed experimentally in neural crest cells, we must either carefully tune our parameters or assume that there is significant cell-to-cell variation in key parameters like cell-cell adhesion.
Year
DOI
Venue
2016
10.1371/journal.pcbi.1005239
PLOS COMPUTATIONAL BIOLOGY
Field
DocType
Volume
Neural crest,Biology,Biophysics,Simulation,Cell migration,Collision,Cell type,Adhesion,Contact inhibition,Genetics,Cell polarity,Motility
Journal
12
Issue
ISSN
Citations 
12
1553-7358
0
PageRank 
References 
Authors
0.34
0
3
Name
Order
Citations
PageRank
Dirk Alexander Kulawiak100.34
brian a camley200.68
Wouter-Jan Rappel3112.42