Name
Title | ||
|---|---|---|
A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation. |
Abstract | ||
|---|---|---|
Contractions on the descending limb of the total (active + passive) muscle force-length relationship (i.e. when muscle stiffness is negative) are expected to lead to vast half-sarcomere-length inhomogeneities. This is however not observed in experiments-vast half-sarcomere-length inhomogeneities can be absent in myofibrils contracting in this range, and initial inhomogeneities can even decrease. Here we show that the absence of half-sarcomere-length inhomogeneities can be predicted when considering interactions of the semi-active protein titin with the actin filaments. Including a model of actin-titin interactions within a multi-scale continuum-mechanical model, we demonstrate that stability, accurate forces and nearly homogeneous half-sarcomere lengths can be obtained on the descending limb of the static total force-length relation. This could be a key to durable functioning of the muscle because large local stretches, that might harm, for example, the transverse-tubule system, are avoided. |
Year | DOI | Venue |
|---|---|---|
2017 | 10.1371/journal.pcbi.1005773 | PLOS COMPUTATIONAL BIOLOGY |
Field | DocType | Volume |
Muscle contraction,Contraction (grammar),Anatomy,Biology,Sarcomere,Biophysics,Skeletal muscle,Titin,Actin,Deformation (mechanics),Myofibril,Bioinformatics | Journal | 13 |
Issue | Citations | PageRank |
10 | 0 | 0.34 |
References | Authors | |
4 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Thomas Heidlauf | 1 | 7 | 2.06 |
| Thomas Klotz | 2 | 0 | 0.34 |
| Christian Rode | 3 | 10 | 1.98 |
| Tobias Siebert | 4 | 6 | 1.12 |
| Oliver Röhrle | 5 | 24 | 8.62 |