Title
Conservation Laws in Biochemical Reaction Networks.
Abstract
We study the existence of linear and nonlinear conservation laws in biochemical reaction networks with mass-action kinetics. It is straightforward to compute the linear conservation laws as they are related to the left null-space of the stoichiometry matrix. The nonlinear conservation laws are difficult to identify and have rarely been considered in the context of mass-action reaction networks. Here, using the Darboux theory of integrability, we provide necessary structural (i.e., parameter-independent) conditions on a reaction network to guarantee the existence of nonlinear conservation laws of a certain type. We give necessary and sufficient structural conditions for the existence of exponential factors with linear exponents and univariate linear Darboux polynomials. This allows us to conclude that nonlinear first integrals only exist under the same structural condition (as in the case of the Lotka-Volterra system). We finally show that the existence of such a first integral generally implies that the system is persistent and has stable steady states. We illustrate our results by examples.
Year
DOI
Venue
2017
10.1137/17M1138418
SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS
Keywords
Field
DocType
Darboux polynomials,dynamical systems,mass-action kinetics,nonlinear conservation law,persistence,Lotka-Volterra system
Applied mathematics,Nonlinear system,Exponential function,Polynomial,Matrix (mathematics),Mathematical analysis,Dynamical systems theory,Univariate,Conservation law,Mathematics,First integrals
Journal
Volume
Issue
ISSN
16
4
1536-0040
Citations 
PageRank 
References 
1
0.36
0
Authors
4
Name
Order
Citations
PageRank
Adam Mahdi182.90
Antoni Ferragut232.03
Cláudia Valls3118.99
Carsten Wiuf420022.96