Title
Chromatin 3D - will it make understanding of cancer transformation finally possible?
Abstract
Despite enormous progress in molecular analysis of cancer cell genomes, the mechanism of tumorigenesis remains unclear. The information present in the genome is not limited to the DNA sequence itself. Indeed, a significant portion of this information is concealed in the spatial structure of chromatin. Ongoing scientific studies that focus on the three-dimensional structure of chromatin raise hopes of arriving at a general explanation of the cancer transformation phenomenon.
Year
DOI
Venue
2018
10.1515/bams-2018-0002
BIO-ALGORITHMS AND MED-SYSTEMS
Keywords
Field
DocType
cancer transformation,chromatin organization,cohesin,CTCF,topologically associated domains (TADs)
Biology,Cell biology,Cohesin,CTCF,Chromatin,Cancer
Journal
Volume
Issue
ISSN
14
1
1895-9091
Citations 
PageRank 
References 
0
0.34
1
Authors
5
Name
Order
Citations
PageRank
Grazyna Drabik100.34
Jolanta Kaszuba-Zwoinska200.34
Zdzisław Wiśniowski333.16
Leszek Konieczny46722.55
Irena Roterman57830.08