Title
Fast And Uncertainty-Aware Cerebral Cortex Morphometry Estimation Using Random Forest Regression
Abstract
The cortical thickness and curvature of the human brain have proven to be valuable markers to detect and monitor neurodegenerative diseases [1]. Since the computational burden of currently available tools for brain morphometry is very high, this analysis often is only used for retrospective studies and not routinely in the clinics. A first attempt at a clinical use of cortical morphology is reported in [2]. We present an experiment for fast morphometry estimations using Random Forest (RF) regression [3] directly from MR imaging data. An uncertainty-aware voxel-wise, parcellation-wise, and multi-output model was built to estimate the thickness and mean curvature of the human cerebral cortex in 15 minutes instead of many hours for mesh-based tools. Preliminary results on a healthy controls database with 315 subjects show a substantial bias for the voxel-wise prediction, but high scan-rescan robustness, the proposed multi-output-parcellation prediction demonstrates the feasibility of the approach.
Year
Venue
Keywords
2018
2018 IEEE 15TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2018)
Human brain morphometry, cortical thickness, cortical curvature, random forest regression, machine learning
Field
DocType
ISSN
Mr imaging,Regression,Pattern recognition,Computer science,Robustness (computer science),Brain morphometry,Human brain,Artificial intelligence,Cerebral cortex,Random forest
Conference
1945-7928
Citations 
PageRank 
References 
1
0.35
0
Authors
4
Name
Order
Citations
PageRank
Yannick Suter110.69
Christian Rummel262.27
Roland Wiest334422.73
Mauricio Reyes47313.74