Paper Info
Title
Changepoint Analysis Of Putamen And Thalamus Subregions In Premanifest Huntington'S Disease
Abstract
Huntington's disease (HD) is a progressive inherited brain disorder that affects cognition, personality and physical abilities. Advanced statistical shape analysis pipelines have shown that region-specific shape abnormalities of the putamen and thalamus begin earlier than clinical onset ("premanifest" period), but the order and pattern of different subregions' abnormalities of those two structures are still unclear. In this paper, we applied a multivariate linear mixed-effects model, in combination with a novel shape diffeomorphometry technique, to identify the changepoints at which the shape morphometry abnormalities of different putamen and thalamus subregions start. Our experimental results revealed that the putamen was affected severely by HD whereas the thalamus was affected in a milder way. The putaminal subregion connected to the executive cortex and the thalamic subregion connected to the prefrontal cortex were found to be affected the earliest by HD. This study contributes to a better understanding of the temporal ordering of the putaminal and thalamic abnormalities of different functionally-distinct subregions.
Year
Venue
Keywords
2018
2018 IEEE 15TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2018)
Changepoint onset model, subregional shape analysis, putamen, thalamus, premanifest Huntington's disease
Field
DocType
ISSN
Thalamus,Cortex (botany),Putamen,Neuroscience,Pattern recognition,Computer science,Statistical shape analysis,Prefrontal cortex,Artificial intelligence,Cognition,Huntington's disease
Conference
1945-7928
Citations 
PageRank 
References 
0
0.34
0
Authors
4
Name
Order
Citations
PageRank
Xiaoqing Tan100.34
Christopher A Ross231.42
Michael I Miller33123422.82
Xiaoying Tang488.79