Title
Interferon induced Mx protein from Indian snow trout Schizothorax richardsonii (Gray) lacks critical functional features unlike its mammalian homologues.
Abstract
•Snow trout Mx protein carries the signature of dynamin family (LPRGTGIVTR) and a tripartite GTP-binding domain (GDQSSGKS, DLPG, and TKPD).•Mx protein is an elongated structure with a G domain, bundle signaling element (BSE) and a GTPase effector domain with two highly conserved leucine zippers at C treminal.•Snow trout Mx lacks the crucial functional features of its mammalian homologues.•A potential ligand binding site was identified in G-domain of Mx.
Year
DOI
Venue
2018
10.1016/j.compbiolchem.2017.12.011
Computational Biology and Chemistry
Keywords
Field
DocType
ISGs,GED,ORF,BSE,Poly (I:C),UTRs
Biology,Cell biology,Coding region,Open reading frame,GTPase,Trout,Homology (biology),G-domain,Leucine zipper,Genetics,Interferon-inducible GTPase
Journal
Volume
ISSN
Citations 
73
1476-9271
0
PageRank 
References 
Authors
0.34
7
4
Name
Order
Citations
PageRank
Ankur Saxena117121.64
Kiran Belwal200.34
Ankita Chauhan300.34
Amit Pande426924.58